Endocrine Abstracts

The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a disorder of impaired water excretion caused by inability to suppress secretion of antidiuretic hormone. The therapy of SIADH varies with severity of hyponatremia and presence or absence of symptoms. Non-peptide vasopressin receptor antagonists (vaptans) are effective at increasing sodium in euvolemic and hypervolemic states and appear safe. We aimed to evaluate the efficacy of tolvaptan in euvolemic h...

Tuberculosis (TB) infection incidence is still high among solid organ transplant recipients. TB in recipients can manifest several years after transplantation, especially in developing countries. Atypical clinical presentations and extrapulmonary involvement are not uncommon in recipients. Herein, we reported a kidney transplant recipient with TB abscess who admitted with fever and swelling on thyroid gland region.Case: A 57-year old female recipient und...

Background: Although hyperthyroidism has many treatment options, hyperthyroidism is difficult to control in some patients. Hyperthyroidism has three main treatment options: antithyroid drugs, radioactive iodine therapy and surgical treatment. However, in some cases none of these treatments can be used. However, there are some patients who failed to respond to radioactive iodine therapy, patients who choose not to receive any one of the options, and others who are poor surgical...

Introduction: Papillary thyroid carcinoma (PTC) is the most common thyroid carcinoma and is derived from thyroid follicular cells which originate from the endodermal origin. In contrast, medullary thyroid carcinoma (MTC) is rare and originates from the parafollicular C-cells, which are commonly thought to be derived from the ectodermal neural crest. Co-incidence of the two condition on the same patient is so rare. We describe a case of concurrent MTC and PTC occurring in the s...

Aims: Medullary thyroid carcinoma (MTC) is a rare endocrine cancer that accounts for approximately 5% of all thyroid cancers. Both the diagnosis and management of MTC could be difficult. Surgery is a main therapy in MTC, chemotherapy and external radiotherapy have limited efficacy. Recently, the relationship between some of the hemocytometer parameters and cancer has been investigated. In this study we aimed to determine the relationship between MTC and hemocytometer parameter...

Introduction: Pheochromocytomas are rare catecolamin-secreting neoplasms. The classic triad of symptoms in patients with a pheochromocytoma consists of episodic headache, sweating and tachycardia. Gastrointestinal spectrums have been reported such as chronic constipation, intestinal pseudo-obstruction or even intestinal perforation. We describe patient who presented with non-mechanical bowel obstruction and interestingly hydronephrosis and acute kidney injury as a consequence ...

Vitamin B12 or cobalamin is mainly found in animal origin food products. The frequency of vitamin B12 deficiency varies between 3 and 40% in different populations. Metformin is the first-choice therapy for type 2 diabetics having some side effects, one of them being vitamin B12 malabsorption. The study aimed to evaluate serum levels of vitamin B12 in diabetic and non-diabetic patients with cobalamin deficiency.Methods: Medical records of subjects having ...

Introduction: High thyroid hormone levels with unsupressed TSH (atypical hyperthyroxinemia) is one of the difficult endocrinologic conditions. When the conditions leading to euthyroid hyperthyoxinism are excluded, TSH secreting pituitary adenomas (TSHoma) and thyroid hormone resistance beta syndrome (THRB) lead to this picture as rare diseases. This report aims to evaluate the diagnostic and therapeutic stages in the case of TSH-secreting pituitary microadenoma which response ...

Background: Pituitary adenomas are usually benign epithelial tumors and they are the most common cause of sellar masses from the third decade on, accounting for up to 10% of all intracranial neoplasms. Pituitary adenomas typically present with neurologic symptoms, clinical findings of hormonal abnormalities or as an incidental finding on magnetic resonance imaging (MRI). Double pituitary adenomas are very rare, and they account for 1% of all pituitary adenomas in autopsy serie...

Introduction: Myxoid adrenocortical adenoma was described by Brown et al. in 2000 (1). Myxoid adrenal cortical adenoma with pseudo glandular structure is a particular histological variant and is extremely rare. Accurate diagnosis is based on the combined evaluation of clinical features, adrenal imaging, and pathological features. Immunohistochemical studies (cytokeratin, melan-A, USP10, chromogranin, vimentin) can distinguish adrenocortical adenoma from other retroperitoneal m...